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Alkene Carboboration Enabled by Synergistic Catalysis
Author(s) -
Smith Kevin B.,
Logan Kaitlyn M.,
You Wei,
Brown M. Kevin
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404310
Subject(s) - alkene , nucleophile , catalysis , aryl , coupling (piping) , chemistry , combinatorial chemistry , in situ , organic chemistry , materials science , alkyl , metallurgy
Abstract A synergistic Pd/Cu system for the coupling of alkenes, (Bpin) 2 (pin=pinacolate), and aryl/vinyl bromides is disclosed. This method allows for the catalytic generation of secondary Csp 3 Cu nucleophiles in situ and subsequent Pd‐catalyzed cross‐coupling.