Premium
An Efficient Rose Bengal Based Nanoplatform for Photodynamic Therapy
Author(s) -
Gianotti Enrica,
Martins Estevão Bianca,
Cucinotta Fabio,
Hioka Noboru,
Rizzi Manuela,
Renò Filippo,
Marchese Leonardo
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404296
Subject(s) - rose bengal , photodynamic therapy , singlet oxygen , xanthene , mesoporous silica , chemistry , nanotechnology , photochemistry , materials science , oxygen , mesoporous material , biochemistry , organic chemistry , catalysis
Organically modified mesoporous silica nanoparticles (MSNs) containing rose bengal (RB), a xanthene dye, were successfully synthesized. RB‐modified MSNs have shown a relevant photostability and a high efficiency in the photoproduction and delivery of singlet oxygen ( 1 O 2 ), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that RB‐MSNs are able to reduce cell proliferation in one of the most aggressive skin cancer types (SK‐MEL‐28) after green‐light irradiation.