Iridium(III)‐Catalyzed CH Amidation of Arylphosphoryls Leading to a  P ‐Stereogenic Center | Zendy

Gwon Donghyeon | Zendy; Lee Donggun | Zendy; Kim Jiyu | Zendy; Park Sehoon | Zendy; Chang Sukbok | Zendy

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Iridium(III)‐Catalyzed CH Amidation of Arylphosphoryls Leading to a P ‐Stereogenic Center

Author(s) -

Gwon Donghyeon,

Lee Donggun,

Kim Jiyu,

Park Sehoon,

Chang Sukbok

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201404151

Subject(s) - stereocenter , diastereomer , iridium , catalysis , center (category theory) , chemistry , reaction conditions , combinatorial chemistry , stereochemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , crystallography

Direct CH amidation of arylphosphoryl compounds has been developed by using an Ir III catalyst system under mild conditions. A wide range of substrates could be employed with high functional‐group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P‐chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de ).

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