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Iridium(III)‐Catalyzed CH Amidation of Arylphosphoryls Leading to a P ‐Stereogenic Center
Author(s) -
Gwon Donghyeon,
Lee Donggun,
Kim Jiyu,
Park Sehoon,
Chang Sukbok
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404151
Subject(s) - stereocenter , diastereomer , iridium , catalysis , center (category theory) , chemistry , reaction conditions , combinatorial chemistry , stereochemistry , medicinal chemistry , enantioselective synthesis , organic chemistry , crystallography
Direct CH amidation of arylphosphoryl compounds has been developed by using an Ir III catalyst system under mild conditions. A wide range of substrates could be employed with high functional‐group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P‐chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de ).