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Versatile Cu I /Pd 0 Dual Catalysis for the Synthesis of Quaternary α‐Allylated Carbonyl Compounds: Development, Mechanistic Investigations and Scope
Author(s) -
Nahra Fady,
Macé Yohan,
Boreux Arnaud,
Billard Francois,
Riant Olivier
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201404015
Subject(s) - catalysis , chemistry , combinatorial chemistry , scope (computer science) , component (thermodynamics) , organic chemistry , physics , computer science , thermodynamics , programming language
We report herein a versatile cooperative dual catalysis reaction based on a Cu I /Pd 0 system. Mechanistic investigation shows that every component plays a crucial role in determining the reaction outcome. The reaction is successfully extended to various substrates; such as α,β‐unsaturated ketones, malonates and coumarins. The strategy tolerates different substitution patterns and affords good yields for each family of substrates.