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Selective Stabilization of Abasic Site‐Containing DNA by Insertion of Sterically Demanding Biaryl Ligands
Author(s) -
Benner Katja,
Bergen Anna,
Ihmels Heiko,
Pithan Phil Marvin
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403622
Subject(s) - steric effects , dna , chemistry , intercalation (chemistry) , ap site , titration , duplex (building) , thermal stability , dissociation (chemistry) , stereochemistry , combinatorial chemistry , biochemistry , dna repair , organic chemistry
Biaryl derivatives that consist of one DNA‐intercalating unit and a sterically demanding component exhibit a specific behavior towards abasic site‐containing DNA (AP‐DNA) as determined by thermal DNA denaturation experiments, spectrometric titrations and CD spectroscopic analysis. Specifically, these ligands strongly stabilize AP‐DNA towards dissociation, whereas they do not or only marginally affect the melting temperature of regular duplex DNA.