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High‐Resolution 3D Proton MRI of Hyperpolarized Gas Enabled by Parahydrogen and Rh/TiO 2 Heterogeneous Catalyst
Author(s) -
Kovtunov Kirill V.,
Barskiy Danila A.,
Coffey Aaron M.,
Truong Milton L.,
Salnikov Oleg G.,
Khudorozhkov Alexander K.,
Inozemtseva Elizaveta A.,
Prosvirin Igor P.,
Bukhtiyarov Valery I.,
Waddell Kevin W.,
Chekmenev Eduard Y.,
Koptyug Igor V.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403604
Subject(s) - spin isomers of hydrogen , hyperpolarization (physics) , propane , induced polarization , chemistry , catalysis , propene , nuclear magnetic resonance , hydrogen , materials science , nuclear magnetic resonance spectroscopy , stereochemistry , biochemistry , physics , organic chemistry , electrical engineering , electrical resistivity and conductivity , engineering
Several supported metal catalysts were synthesized, characterized, and tested in heterogeneous hydrogenation of propene with parahydrogen to maximize nuclear spin hyperpolarization of propane gas using parahydrogen induced polarization (PHIP). The Rh/TiO 2 catalyst with a metal particle size of 1.6 nm was found to be the most active and effective in the pairwise hydrogen addition and robust, demonstrating reproducible results with multiple hydrogenation experiments and stability for ≥1.5 years. 3D 1 H magnetic resonance imaging (MRI) of 1 % hyperpolarized flowing gas with microscale spatial resolution (625×625×625 μm 3 ) and large imaging matrix (128×128×32) was demonstrated by using a preclinical 4.7 T scanner and 17.4 s imaging scan time.