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Scalable, Transition‐Metal‐Free Direct Oxime O ‐Arylation: Rapid Access to O ‐Arylhydroxylamines and Substituted Benzo[ b ]furans
Author(s) -
Gao Hongyin,
Xu QingLong,
Keene Craig,
Kürti László
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403519
Subject(s) - chemistry , oxime , transition metal , hydrolysis , sequence (biology) , sigmatropic reaction , combinatorial chemistry , stereochemistry , medicinal chemistry , organic chemistry , catalysis , biochemistry
Abstract O ‐Aryloximes, generated from readily available and inexpensive oximes through transition‐metal‐free O ‐arylation, can either be hydrolyzed to O ‐arylhydroxylamines or conveniently converted to structurally diverse benzo[ b ]furans through an environmentally benign, one‐pot [3,3]‐sigmatropic rearrangement/cyclization sequence.