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Multifunctional Inorganic Nanocontainers for DNA and Drug Delivery into Living Cells
Author(s) -
Lülf Henning,
Bertucci Alessandro,
Septiadi Dedy,
Corradini Roberto,
De Cola Luisa
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403232
Subject(s) - drug delivery , nanotechnology , nanomedicine , nanomaterials , dna , molecule , nanobiotechnology , nanoparticle , materials science , gene delivery , oligonucleotide , biomedicine , chemistry , genetic enhancement , organic chemistry , gene , biochemistry , bioinformatics , biology
The design and synthesis of multifunctional nanomaterials could lead to applications relevant for biomedicine. Manufacturing porous particles to make them able to carry bioactive molecules into living cells represents a substantial goal towards the development of powerful tools for nanomedicine. This work describes a first example of using zeolite‐L crystals as multifunctional nanocontainers to simultaneously deliver DNA oligonucleotides and organic molecules into living cells. Multifunctional zeolite‐L was prepared by filling the pore system with guest molecules, whilst DNA was adsorbed electrostatically on their surface. The release kinetics of DNA and of the guest molecules into living cells was studied to prove the multiple‐drug‐delivery ability of the system. The localization of all the components in different cellular compartments was followed. The presented system may be a prototype for the development of novel nanoparticles for drug delivery and gene therapy.