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Silica‐Encapsulated Gd 3+ ‐Aggregated Gold Nanoclusters for In Vitro and In Vivo Multimodal Cancer Imaging
Author(s) -
Wu Xiaotong,
Li Chunxia,
Liao Suchan,
Li Lu,
Wang Tingting,
Su Zhongmin,
Wang Chungang,
Zhao Jihong,
Sui Changping,
Lin Jun
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403202
Subject(s) - nanoclusters , in vivo , fluorescence , in vitro , colloidal gold , materials science , magnetic resonance imaging , nanoparticle , nanotechnology , preclinical imaging , nuclear magnetic resonance , biophysics , chemistry , biochemistry , medicine , optics , radiology , physics , microbiology and biotechnology , biology
Gd 3+ ‐aggregated gold nanoclusters (AuNCs) encapsulated by silica shell (Gd 3+ ‐A‐AuNCs@SiO 2 NPs) were strategically designed and prepared. The as‐prepared nanoparticles exhibit aggregation‐enhanced fluorescence (AEF), with an intensity that is up to 3.8 times that of discrete AuNCs. The clusters served as novel nanoprobes for in vitro and in vivo multimodal (fluorescence, magnetic resonance, and computed X‐ray tomography) cancer imaging