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Copper‐Catalyzed Aerobic Oxidative Inert CC and CN Bond Cleavage: A New Strategy for the Synthesis of Tertiary Amides
Author(s) -
Chen Xiuling,
Chen Tieqiao,
Li Qiang,
Zhou Yongbo,
Han LiBiao,
Yin ShuangFeng
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403144
Subject(s) - catalysis , chemistry , bond cleavage , oxidative phosphorylation , inert , copper , oxygen , cleavage (geology) , organic synthesis , molecular oxygen , combinatorial chemistry , inert gas , organic chemistry , medicinal chemistry , biochemistry , materials science , fracture (geology) , composite material
A copper‐catalyzed aerobic oxidative amidation reaction of inert CC bonds with tertiary amines has been developed for the synthesis of tertiary amides, which are significant units in many natural products, pharmaceuticals, and fine chemicals. This method combines CC bond activation, CN bond cleavage, and CH bond oxygenation in a one‐pot protocol, using molecular oxygen as the sole oxidant without any additional ligands.