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Peptides Come Round: Using SICLOPPS Libraries for Early Stage Drug Discovery
Author(s) -
Lennard Katherine R.,
Tavassoli Ali
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201403117
Subject(s) - intein , drug discovery , cyclic peptide , computational biology , peptide , combinatorial chemistry , biology , chemistry , biochemistry , gene , rna splicing , rna
Cyclic peptides are an emerging class of molecular therapeutics that are increasingly viewed as ideal backbones for modulation of protein–protein interactions. A split‐intein based method, termed SICLOPPS, enables the rapid generation of genetically encoded cyclic peptide libraries of around a hundred million members. Here we review recent approaches using SICLOPPS for the discovery of bioactive compounds.