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Convenient Synthesis of Functionalized Bis‐ureidopyrimidinones Based on Thiol‐yne Reaction
Author(s) -
Peng HuiQing,
Sun CaiLi,
Xu JiangFei,
Niu LiYa,
Chen YuZhe,
Wu LiZhu,
Tung ChenHo,
Yang QingZheng
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402955
Subject(s) - thiol , simplicity , combinatorial chemistry , chemistry , organic chemistry , philosophy , epistemology
The preparation of functionalized bis‐ureidopyrimidinones ( Bis‐UPy ) through the thiol‐yne reaction is described. Various Bis‐UPys with different functional groups were synthesized by using the readily available functionalized alkynes and UPy‐thiol to affirm the simplicity and versatility of the methodology.