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Palladium‐Catalyzed Carbonylative α‐Arylation to β‐Ketonitriles
Author(s) -
Schranck Johannes,
Burhardt Mia,
Bornschein Christoph,
Neumann Helfried,
Skrydstrup Troels,
Beller Matthias
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402893
Subject(s) - nitrile , palladium , moiety , carbonylation , catalysis , aryl , chemistry , combinatorial chemistry , labelling , organic chemistry , carbon monoxide , biochemistry , alkyl
A carbonylative α‐arylation process employing unactivated nitriles for the first time is described. The reaction tolerates a range of (hetero)aryl iodides and several nitrile coupling partners. No prefunctionalization of the nitriles is necessary and the resulting β‐ketonitriles are obtained in good to excellent yields. The methodology also allows for a convenient 13 C‐labelling of the generated carbonyl moiety.