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A Magnetically Drivable Nanovehicle for Curcumin with Antioxidant Capacity and MRI Relaxation Properties
Author(s) -
Magro Massimiliano,
Campos René,
Baratella Davide,
Lima Giuseppina,
Holà Katerina,
Divoky Clemens,
Stollberger Rudolf,
Malina Ondrej,
Aparicio Claudia,
Zoppellaro Giorgio,
Zbořil Radek,
Vianello Fabio
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402820
Subject(s) - curcumin , maghemite , chemistry , redox , superparamagnetism , nanoparticle , hydroquinone , ferrocyanide , hydrogen peroxide , nuclear chemistry , materials science , nanotechnology , inorganic chemistry , organic chemistry , biochemistry , magnetization , physics , quantum mechanics , magnetic field , electrode
Curcumin possesses wide‐ranging anti‐inflammatory and anti‐cancer properties and its biological activity can be linked to its potent antioxidant capacity. Superparamagnetic maghemite (γ‐Fe 2 O 3 ), called surface‐active maghemite nanoparticles (SAMNs) were surface‐modified with curcumin molecules, due to the presence of under‐coordinated Fe III atoms on the nanoparticle surface. The so‐obtained curcumin‐modified SAMNs (SAMN@curcumin) had a mean size of 13±4 nm. SAMN@curcumin was characterized by transmission and scanning electron microscopy, UV/Vis, FTIR, and Mössbauer spectroscopy, X‐ray powder diffraction, bulk susceptibility (SQUID), and relaxometry measurements (MRI imaging). The high negative contrast proclivity of SAMN@curcumin to act as potential contrast agent in MRI screenings was also tested. Moreover, the redox properties of bound curcumin were probed by electrochemistry. SAMN@curcumin was studied in the presence of different electroactive molecules, namely hydroquinone, NADH and ferrocyanide, to assess its redox behavior. Finally, SAMN@curcumin was electrochemically probed in the presence of hydrogen peroxide, demonstrating the stability and reactivity of bound curcumin.