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Multifunctional 8‐Hydroxyquinoline‐Appended Cyclodextrins as New Inhibitors of Metal‐Induced Protein Aggregation
Author(s) -
Oliveri Valentina,
Attanasio Francesco,
Puglisi Antonino,
Spencer John,
Sgarlata Carmelo,
Vecchio Graziella
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402690
Subject(s) - chemistry , context (archaeology) , amyloid fibril , 8 hydroxyquinoline , metal ions in aqueous solution , amyloid (mycology) , metal , combinatorial chemistry , protein aggregation , biophysics , biochemistry , amyloid β , organic chemistry , biology , medicine , inorganic chemistry , paleontology , disease , pathology
Mounting evidence suggests a pivotal role of metal imbalances in protein misfolding and amyloid diseases. As such, metal ions represent a promising therapeutic target. In this context, the synthesis of chelators that also contain complementary functionalities to combat the multifactorial nature of neurodegenerative diseases is a highly topical issue. We report two new 8‐hydroxyquinoline‐appended cyclodextrins and highlight their multifunctional properties, including their Cu II and Zn II binding abilities, and capacity to act as antioxidants and metal‐induced antiaggregants. In particular, the latter property has been applied in the development of an effective assay that exploits the formation of amyloid fibrils when β‐lactoglobulin A is heated in the presence of metal ions.