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Copper‐Free Click‐Chemistry Platform to Functionalize Cisplatin Prodrugs
Author(s) -
Pathak Rakesh K.,
McNitt Christopher D.,
Popik Vladimir V.,
Dhar Shanta
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402573
Subject(s) - prodrug , click chemistry , cisplatin , combinatorial chemistry , chemistry , cycloaddition , platinum , nanotechnology , computer science , organic chemistry , materials science , catalysis , biochemistry , chemotherapy , medicine , surgery
The ability to rationally design and construct a platform technology to develop new platinum(IV) [Pt IV ] prodrugs with functionalities for installation of targeting moieties, delivery systems, fluorescent reporters from a single precursor with the ability to release biologically active cisplatin by using well‐defined chemistry is critical for discovering new platinum‐based therapeutics. With limited numbers of possibilities considering the sensitivity of Pt IV centers, we used a strain‐promoted azide–alkyne cycloaddition approach to provide a platform, in which new functionalities can easily be installed on cisplatin prodrugs from a single Pt IV precursor. The ability of this platform to be incorporated in nanodelivery vehicle and conjugation to fluorescent reporters were also investigated.