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Nickel‐Catalyzed Decarboxylative Acylation of Heteroarenes by sp 2 CH Functionalization
Author(s) -
Yang Ke,
Zhang Cheng,
Wang Peng,
Zhang Yan,
Ge Haibo
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402516
Subject(s) - surface modification , acylation , catalysis , nickel , chemistry , azole , combinatorial chemistry , decarboxylation , ligand (biochemistry) , organic chemistry , antifungal , biochemistry , receptor , medicine , dermatology
Nickel‐catalyzed ligand‐free decarboxylative cross‐coupling of azole derivatives with α‐oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross‐coupling reactions, in a CH bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Additionally, this approach provides an efficient access to azole ketones, an important structural motif in many medicinal compounds with a broad range of biological activities.