Nickel‐Catalyzed Decarboxylative Acylation of Heteroarenes by sp 2  CH Functionalization | Zendy

Yang Ke | Zendy; Zhang Cheng | Zendy; Wang Peng | Zendy; Zhang Yan | Zendy; Ge Haibo | Zendy

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Nickel‐Catalyzed Decarboxylative Acylation of Heteroarenes by sp 2 CH Functionalization

Author(s) -

Yang Ke,

Zhang Cheng,

Wang Peng,

Zhang Yan,

Ge Haibo

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201402516

Subject(s) - surface modification , acylation , catalysis , nickel , chemistry , azole , combinatorial chemistry , decarboxylation , ligand (biochemistry) , organic chemistry , antifungal , biochemistry , receptor , medicine , dermatology

Nickel‐catalyzed ligand‐free decarboxylative cross‐coupling of azole derivatives with α‐oxoglyoxylic acids has been developed. This work represents the first example of decarboxylative cross‐coupling reactions, in a CH bond functionalization manner, through nickel catalysis, and tolerates various functional groups. Additionally, this approach provides an efficient access to azole ketones, an important structural motif in many medicinal compounds with a broad range of biological activities.

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