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Rhodium‐Catalyzed Intramolecular [3+2+2] Cycloadditions between Alkylidenecyclopropanes, Alkynes, and Alkenes
Author(s) -
Araya Marisel,
Gulías Moisés,
Fernández Israel,
Bhargava Gaurav,
Castedo Luis,
Mascareñas José Luis,
López Fernando
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402473
Subject(s) - cycloaddition , intramolecular force , chemoselectivity , rhodium , catalysis , chemistry , intramolecular reaction , combinatorial chemistry , medicinal chemistry , stereochemistry , organic chemistry
A Rh‐catalyzed intramolecular [3+2+2] cycloaddition is reported. The cycloaddition affords synthetically relevant 5,7,5‐fused tricyclic systems of type 2 from readily available dienyne precursors. The transformation takes place with moderate or good yields, high diastereoselectivity, and total chemoselectivity.