CH Oxygenation and  N ‐Trifluoroacylation of Arylamines Under Metal‐Free Conditions: A Convenient Approach to 2‐Aminophenols and  N ‐Trifluoroacyl‐ ortho ‐aminophenols | Zendy

Venkateswarlu Vunnam | Zendy; Kumar K. A. Aravinda | Zendy; Balgotra Shilpi | Zendy; Reddy G. Lakshma | Zendy; Srinivas M. | Zendy; Vishwakarma Ram A. | Zendy; Sawant Sanghapal D. | Zendy

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CH Oxygenation and N ‐Trifluoroacylation of Arylamines Under Metal‐Free Conditions: A Convenient Approach to 2‐Aminophenols and N ‐Trifluoroacyl‐ ortho ‐aminophenols

Author(s) -

Venkateswarlu Vunnam,

Kumar K. A. Aravinda,

Balgotra Shilpi,

Reddy G. Lakshma,

Srinivas M.,

Vishwakarma Ram A.,

Sawant Sanghapal D.

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201402411

Subject(s) - chemistry , hydroxylation , substrate (aquarium) , oxygenation , combinatorial chemistry , metal , medicinal chemistry , organic chemistry , ecology , oceanography , biology , enzyme , geology

Direct ortho ‐hydroxylation through CH oxygenation and N ‐trifluoroacylation of anilines was achieved in a single step under metal‐free conditions by using a combination of TFA and oxone. The method allowed the formation of functionalised amino phenolic compounds such as ortho ‐hydroxy‐ N ‐trifluoroacetanilides in good yields with broad substrate scope.

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