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CH Oxygenation and N ‐Trifluoroacylation of Arylamines Under Metal‐Free Conditions: A Convenient Approach to 2‐Aminophenols and N ‐Trifluoroacyl‐ ortho ‐aminophenols
Author(s) -
Venkateswarlu Vunnam,
Kumar K. A. Aravinda,
Balgotra Shilpi,
Reddy G. Lakshma,
Srinivas M.,
Vishwakarma Ram A.,
Sawant Sanghapal D.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402411
Subject(s) - chemistry , hydroxylation , substrate (aquarium) , oxygenation , combinatorial chemistry , metal , medicinal chemistry , organic chemistry , ecology , oceanography , biology , enzyme , geology
Direct ortho ‐hydroxylation through CH oxygenation and N ‐trifluoroacylation of anilines was achieved in a single step under metal‐free conditions by using a combination of TFA and oxone. The method allowed the formation of functionalised amino phenolic compounds such as ortho ‐hydroxy‐ N ‐trifluoroacetanilides in good yields with broad substrate scope.