Hypoiodite‐Mediated Cyclopropanation of Alkenes | Zendy

Yoshimura Akira | Zendy; Koski Steven R. | Zendy; Kastern Brent J. | Zendy; Fuchs Jonathan M. | Zendy; Jones T. Nicholas | Zendy; Yusubova Roza Y. | Zendy; Nemykin Victor N. | Zendy; Zhdankin Viktor V. | Zendy

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Hypoiodite‐Mediated Cyclopropanation of Alkenes

Author(s) -

Yoshimura Akira,

Koski Steven R.,

Kastern Brent J.,

Fuchs Jonathan M.,

Jones T. Nicholas,

Yusubova Roza Y.,

Nemykin Victor N.,

Zhdankin Viktor V.

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201402372

Subject(s) - cyclopropanation , malononitrile , chemistry , reaction mechanism , combinatorial chemistry , mechanism (biology) , organic chemistry , catalysis , physics , quantum mechanics

An efficient, transition metal‐free procedure for the cyclopropanation of alkenes using malononitrile and the LiI‐ t BuOCl combination under mild reaction conditions is described. The reaction mechanism most likely involves t BuOI generated in situ from LiI and t BuOCl. The utility of this new methodology has been demonstrated by the synthesis of a potential HIV‐1 RT inhibitor.

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