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A Selective Release System Based on Dual‐Drug‐Loaded Mesoporous Silica for Nanoparticle‐Assisted Combination Therapy
Author(s) -
Wang Wenqian,
Wen Yongqiang,
Xu Liping,
Du Hongwu,
Zhou Yabin,
Zhang Xueji
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402334
Subject(s) - nanomedicine , mesoporous silica , drug delivery , nanotechnology , controlled release , dual (grammatical number) , drug , nanoparticle , materials science , cancer therapy , mesoporous material , chemistry , cancer , pharmacology , medicine , organic chemistry , catalysis , art , literature
Abstract A selective release system was demonstrated with a dual‐cargo loaded MSNs. When stimulated by different signals (UV or H + ), this system could selectively release different kinds of cargoes individually. Furthermore, this system has been used to provide a combination of chemotherapy and biotherapy for cancer treatment. This controlled release system could be an important step in the development of more effective and sophisticated nanomedicine and nanodevices, due to the possibility of selective release of a complex multi‐drug.