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The Use of Cobalt‐Mediated Cycloisomerisation of Ynedinitriles in the Synthesis of Pyridazinohelicenes
Author(s) -
Chercheja Serghei,
Klívar Jiří,
Jančařík Andrej,
Rybáček Jiří,
Salzl Simon,
Tarábek Ján,
Pospíšil Lubomír,
Vacek Chocholoušová Jana,
Vacek Jaroslav,
Pohl Radek,
Císařová Ivana,
Starý Ivo,
Stará Irena G.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402312
Subject(s) - cobalt , materials science , metallurgy
A cobalt‐mediated [2+2+2] cycloisomerisation of ynedinitriles to helical pyridazines in good to high yields was developed. The construction of the pyridazine nucleus from one alkyne and two nitrile units is proposed to follow either a conventional organometallic mechanism or to be triggered by a single‐electron transfer from a Co II species. Various [5]‐, [6]‐ and [7]helicene pyridazines were prepared.