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Reductive Cross‐Coupling Reactions between Two Electrophiles
Author(s) -
Knappke Christiane E. I.,
Grupe Sabine,
Gärtner Dominik,
Corpet Martin,
Gosmini Corinne,
Jacobi von Wangelin Axel
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402302
Subject(s) - electrophile , reagent , aryl , reductive elimination , combinatorial chemistry , coupling reaction , chemistry , alkyl , catalysis , coupling (piping) , organic chemistry , materials science , metallurgy
Reductive cross‐electrophile coupling reactions have recently been developed to a versatile and sustainable synthetic tool for selective CC bond formation. The employment of cheap and abundant electrophiles avoids the pre‐formation and handling of organometallic reagents. In situ reductive coupling is effected in the presence of a transition‐metal catalyst (Ni, Co, Pd, Fe) and a suitable metallic reductant (Mn, Zn, Mg). This Concept article assesses the current state of the art and summarizes recent protocols with various combinations of alkyl, alkenyl, allyl, and aryl reagents and highlights key mechanistic studies.