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Synthesis of Fluorinated Heteroaromatics through Formal Substitution of a Nitro Group by Fluorine under Transition‐Metal‐Free Conditions
Author(s) -
Guo RanNing,
Cai XianFeng,
Shi Lei,
Chen ZhangPei,
Zhou YongGui
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402282
Subject(s) - fluorine , nitro , transition metal , chemistry , electrophilic fluorination , electrophile , substitution (logic) , combinatorial chemistry , group (periodic table) , computational chemistry , organic chemistry , computer science , catalysis , alkyl , programming language
An efficient and transition‐metal‐free approach was developed to access a series of fluorinated heteroaromatics in moderate to excellent yields. This one‐pot procedure features a triple‐relay transformation of rapid dearomatization, fluorination, and rearomatization processes, which represents a conceptually novel strategy of combining partial hydrogenation and electrophilic fluorination.