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Influence of Catalyst Structure and Reaction Conditions on anti ‐ versus syn ‐Aminopalladation Pathways in Pd‐Catalyzed Alkene Carboamination Reactions of N ‐Allylsulfamides
Author(s) -
Fornwald Ryan M.,
Fritz Jonathan A.,
Wolfe John P.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402258
Subject(s) - alkene , catalysis , chemistry , aryl , coupling reaction , sulfamide , medicinal chemistry , organic chemistry , alkyl
The Pd‐catalyzed coupling of N ‐allylsulfamides with aryl and alkenyl triflates to afford cyclic sulfamide products is described. In contrast to other known Pd‐catalyzed alkene carboamination reactions, these transformations may be selectively induced to occur by way of either anti ‐ or syn ‐aminopalladation mechanistic pathways by modifying the catalyst structure and reaction conditions.