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Taming Living Carbocations in Catalytic Direct Conjugate Addition of Simple Alkenes to α,β‐Enones
Author(s) -
Lv Jian,
Zhong Xingren,
Luo Sanzhong
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402246
Subject(s) - carbocation , conjugate , chemistry , catalysis , ligand (biochemistry) , adduct , lewis acids and bases , addition reaction , combinatorial chemistry , medicinal chemistry , organic chemistry , receptor , mathematical analysis , biochemistry , mathematics
A Lewis acid in the presence of an anionic phosphate ligand enables the addition of alkenes to α,β‐enones. The ligand facilitates selective β‐proton elimination by suppressing competing pathways, thus leading to vinylation adducts in high yields (up to 99 %) for a broad range of substrates.