General Catalytic Methylation of Amines with Formic Acid under Mild Reaction Conditions | Zendy

Sorribes Iván | Zendy; Junge Kathrin | Zendy; Beller Matthias | Zendy

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General Catalytic Methylation of Amines with Formic Acid under Mild Reaction Conditions

Author(s) -

Sorribes Iván,

Junge Kathrin,

Beller Matthias

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201402124

Subject(s) - formic acid , silanes , primary (astronomy) , catalysis , chemistry , methylation , organic chemistry , combinatorial chemistry , biochemistry , physics , silane , astronomy , gene

A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C 1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [ N ‐ 13 C]‐labelled drugs in good to excellent yields under mild conditions.

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