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General Catalytic Methylation of Amines with Formic Acid under Mild Reaction Conditions
Author(s) -
Sorribes Iván,
Junge Kathrin,
Beller Matthias
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402124
Subject(s) - formic acid , silanes , primary (astronomy) , catalysis , chemistry , methylation , organic chemistry , combinatorial chemistry , biochemistry , physics , silane , astronomy , gene
A general catalytic protocol for the methylation of amines has been developed applying, for the first time, formic acid as the C 1 building block and silanes as reducing agents. A broad range of aromatic and aliphatic, both primary and secondary, amines has been converted to the corresponding tertiary amines including [ N ‐ 13 C]‐labelled drugs in good to excellent yields under mild conditions.