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Direct Metal‐Catalyzed Regioselective Functionalization of Enamides
Author(s) -
Gigant Nicolas,
ChaussetBoissarie Laëtitia,
Gillaizeau Isabelle
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201402070
Subject(s) - regioselectivity , surface modification , enamine , nitrogen atom , combinatorial chemistry , chemistry , catalysis , reactivity (psychology) , organic chemistry , ring (chemistry) , medicine , alternative medicine , pathology
Enamides are stable enamine surrogates and provide key intermediates for the synthesis of small but complex nitrogen‐containing compounds. Metal‐catalyzed regioselective functionalization of enamides provides a rapid method to synthesize useful nitrogen containing heterocycles. This review discloses the recent progress made in the development of the CH functionalization of enamides involving efficient and atom‐economical routes. Syntheses of different heterocycles are classified based on the site reactivity of enamides and key mechanistic insights are given for each transformation.