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Ru‐Catalyzed Branched versus Linear Selective C3‐Alkylation of 2‐Aroylbenzofurans with Acrylates via CH Activation
Author(s) -
Kommagalla Yadagiri,
Srinivas Kolluru,
Ramana Chepuri V.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400401
Subject(s) - steric effects , alkylation , catalysis , chemistry , selectivity , medicinal chemistry , stereochemistry , organic chemistry
Abstract The carbonyl‐directed C3H activation and alkylation of 2‐aroylbenzo[ b ]furans with acrylates occurs selectively either in a linear or branched fashion, depending on the catalyst employed; [Ru( p ‐cymene)Cl 2 ] 2 or Ru(PPh 3 ) 3 Cl 2 , respectively. Two alternate pathways—funded upon the differences in steric and electronic preferences of these two complexes—is proposed for the selectivity of linear versus branched products.