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Facile Preparation of Core–Shell Magnetic Metal–Organic Framework Nanospheres for the Selective Enrichment of Endogenous Peptides
Author(s) -
Xiong Zhichao,
Ji Yongsheng,
Fang Chunli,
Zhang Quanqing,
Zhang Lingyi,
Ye Mingliang,
Zhang Weibing,
Zou Hanfa
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400389
Subject(s) - shell (structure) , metal , chemistry , metal organic framework , core (optical fiber) , endogeny , nanotechnology , chemical engineering , combinatorial chemistry , materials science , organic chemistry , biochemistry , engineering , composite material , adsorption
Facile preparation of core–shell magnetic metal–organic framework nanospheres by a layer‐by‐layer approach is presented. The nanospheres have high surface area (285.89 cm 2 g −1 ), large pore volume (0.18 cm 3 g −1 ), two kinds of mesopores (2.50 and 4.72 nm), excellent magnetic responsivity (55.65 emu g −1 ), structural stability, and good dispersibility. The combination of porosity, hydrophobicity, and uniform magnetism was exploited for effective enrichment of peptides with simultaneous exclusion of high molecular weight proteins. The nanospheres were successfully applied in the selective enrichment of endogenous peptides in human serum.