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Yoctowell Cavities on Magnetic Silica Nanoparticles for pH Stimuli‐Responsive Controlled Release of Drug Molecules
Author(s) -
Bhosale Sheshanath V.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400279
Subject(s) - drug delivery , controlled release , nanoparticle , magnetic nanoparticles , nanotechnology , molecule , chemistry , drug , biophysics , chemical engineering , materials science , organic chemistry , pharmacology , medicine , engineering , biology
Drug‐delivery systems that medically transport active molecules to diseased cells, in a controlled manner, have gained much attention in recent years. Yoctowell (1 yL=8 nm 3 that is, 10 −24 L volume) cavities on magnetic silica nanoparticles were used for the encapsulation and release of the drug molecule, “mitoxantrone ( MTZ )”, and controlled using naturally occurring stimuli, that is, pH. First, MTZ was encapsulated from a bulk solution under physiological conditions, and then released from the yoctowells, in a controlled manner, by manipulating the pH (7.2–3.0). The sustained release of MTZ , the recovery of active yoctowells after the release process and magnetic properties of nanoparticles provide potential for development of a new generation of drug‐delivery system.