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A Fully Synthetic Glycopeptide Antitumor Vaccine Based on Multiple Antigen Presentation on a Hyperbranched Polymer
Author(s) -
Glaffig Markus,
Palitzsch Björn,
Hartmann Sebastian,
Schüll Christoph,
Nuhn Lutz,
Gerlitzki Bastian,
Schmitt Edgar,
Frey Holger,
Kunz Horst
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400256
Subject(s) - glycopeptide , immune system , antigen presentation , antigen , epitope , toxoid , click chemistry , muc1 , dendrimer , antibody , tumor antigen , immunology , chemistry , medicine , immunotherapy , t cell , biochemistry , immunization , combinatorial chemistry , antibiotics
For antitumor vaccines both the selected tumor‐associated antigen, as well as the mode of its presentation, affect the immune response. According to the principle of multiple antigen presentation, a tumor‐associated MUC1 glycopeptide combined with the immunostimulating T‐cell epitope P2 from tetanus toxoid was coupled to a multi‐functionalized hyperbranched polyglycerol by “click chemistry”. This globular polymeric carrier has a flexible dendrimer‐like structure, which allows optimal antigen presentation to the immune system. The resulting fully synthetic vaccine induced strong immune responses in mice and IgG antibodies recognizing human breast‐cancer cells.