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Ruthenium(II)‐Catalyzed Synthesis of Isochromenes by CH Activation with Weakly Coordinating Aliphatic Hydroxyl Groups
Author(s) -
Nakanowatari Sachiyo,
Ackermann Lutz
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400161
Subject(s) - annulation , cationic polymerization , ruthenium , chemistry , metalation , catalysis , surface modification , medicinal chemistry , combinatorial chemistry , polymer chemistry , organic chemistry
Cationic ruthenium(II) complexes have been employed for the highly effective oxidative annulation of alkynes with benzyl alcohols to deliver diversely decorated isochromenes. The hydroxyl‐directed CH/OH functionalization process proceeded efficiently under an atmosphere of air. Detailed mechanistic studies were indicative of a kinetically relevant CH metalation.