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Dual‐Frequency Calcium‐Responsive MRI Agents
Author(s) -
Kadjane Pascal,
PlatasIglesias Carlos,
BoehmSturm Philipp,
Truffault Vincent,
Hagberg Gisela E.,
Hoehn Mathias,
Logothetis Nikos K.,
Angelovski Goran
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400159
Subject(s) - magnetic resonance imaging , nuclear magnetic resonance , calcium , signal (programming language) , paramagnetism , chemistry , computer science , physics , medicine , radiology , organic chemistry , quantum mechanics , programming language
Responsive or smart magnetic resonance imaging (MRI) contrast agents are molecular sensors that alter the MRI signal upon changes in a particular parameter in their microenvironment. Consequently, they could be exploited for visualization of various biochemical events that take place at molecular and cellular levels. In this study, a set of dual‐frequency calcium‐responsive MRI agents are reported. These are paramagnetic, fluorine‐containing complexes that produce remarkably high MRI signal changes at the 1 H and 19 F frequencies at varying Ca 2+ concentrations. The nature of the processes triggered by Ca 2+ was revealed, allowing a better understanding of these complex systems and their further improvement. The findings indicate that these double‐frequency tracers hold great promise for development of novel functional MRI methods.