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Inhibition of Amyloid Fibril Growth and Dissolution of Amyloid Fibrils by Curcumin–Gold Nanoparticles
Author(s) -
Palmal Sharbari,
Maity Amit Ranjan,
Singh Brijesh Kumar,
Basu Sreetama,
Jaihar R.,
Jaikhil R.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201400079
Subject(s) - curcumin , fibril , amyloid (mycology) , fibrillation , amyloid fibril , chemistry , colloidal gold , nanoparticle , peptide , biophysics , protein aggregation , amyloid disease , biochemistry , amyloid β , nanotechnology , materials science , disease , medicine , biology , inorganic chemistry , atrial fibrillation
Inhibition of amyloid fibrillation and clearance of amyloid fibrils/plaques are essential for the prevention and treatment of various neurodegenerative disorders involving protein aggregation. Herein, we report curcumin‐functionalized gold nanoparticles (Au‐curcumin) of hydrodynamic diameter 10–25 nm, which serve to inhibit amyloid fibrillation and disintegrate/dissolve amyloid fibrils. In nanoparticle form, curcumin is water‐soluble and can efficiently interact with amyloid protein/peptide, offering enhanced performance in inhibiting amyloid fibrillation and dissolving amyloid fibrils. Our results imply that nanoparticle‐based artificial molecular chaperones may offer a promising therapeutic approach to combat neurodegenerative disease.