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Cover Picture: Histone‐Deacetylase‐Targeted Fluorescent Ruthenium(II) Polypyridyl Complexes as Potent Anticancer Agents (Chem. Eur. J. 31/2013)
Author(s) -
Ye RuiRong,
Ke ZhuoFeng,
Tan CaiPing,
He Liang,
Ji LiangNian,
Mao ZongWan
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201390113
Subject(s) - ruthenium , histone deacetylase , chemistry , fluorescence , apoptosis , acetylation , histone , cancer research , biochemistry , biology , dna , catalysis , physics , quantum mechanics , gene
Fluorescent ruthenium complexes have been used as inhibitors of histone deacetylases (HDACs). In their Full Paper on page 10160 ff. , Z.‐W Mao, C.‐P. Tan, and co‐workers report a series of red fluorescent ruthenium(II) complexes that can inhibit HDAC and induce apoptotic cell death in tumor cells. These fluorescent Ru II ‐HDACi conjugates represent a promising class of anticancer agents for potential dual imaging and therapeutic applications targeting HDACs (cover graphic by Mu‐Qiang Wei).