Premium
Back Cover: Synthesis of Multivalent Carbohydrate‐Centered Glycoclusters as Nanomolar Ligands of the Bacterial Lectin LecA from Pseudomonas aeruginosa (Chem. Eur. J. 28/2013)
Author(s) -
Gening Marina L.,
Titov Denis V.,
Cecioni Samy,
Audfray Aymeric,
Gerbst Alexey G.,
Tsvetkov Yury E.,
Krylov Vadim B.,
Imberty Anne,
Nifantiev Nikolay E.,
Vidal Sébastien
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201390104
Subject(s) - bacterial adhesin , chemistry , lectin , pseudomonas aeruginosa , biofilm , linker , carbohydrate , combinatorial chemistry , biochemistry , stereochemistry , escherichia coli , bacteria , biology , genetics , computer science , gene , operating system
Oligodentate glycoclusters with cyclic oligo‐(1→6)‐β‐ D ‐glucosamines as a core element, as well as forms consisting of glucose and glucosamine units, have been prepared. High hydrophilicity of the carbohydrate scaffolds imparts water solubility and the hydrophobic aromatic linker facilitates better affinity to the protein target. Evaluation of binding towards adhesin (lectin) LecA from Pseudomonas aeruginosa showed that the di‐ and tetradentate ligands possess affinity to the adhesin greatly exceeding (>10 3 times) that of a monodentate reference blocker. For more details see the Full Paper by S. Vidal, N.E. Nifantiev, A. Imberty et al. on page 9272 ff.