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Cover Picture: How Is a Metabolic Intermediate Formed in the Mechanism‐Based Inactivation of Cytochrome P450 by Using 1,1‐Dimethylhydrazine: Hydrogen Abstraction or Nitrogen Oxidation? (Chem. Eur. J. 23/2013)
Author(s) -
Hirao Hajime,
Chuanprasit Pratanphorn,
Cheong Ying Yi,
Wang Xiaoqing
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201390081
Subject(s) - mechanism (biology) , hydrazine (antidepressant) , cytochrome p450 , hydrogen atom abstraction , chemistry , hydrogen bond , molecular nitrogen , enzyme , stereochemistry , combinatorial chemistry , nitrogen , biochemistry , radical , organic chemistry , molecule , philosophy , epistemology
Mechanism‐based inactivation (MBI) of cytochrome P450 (P450) enzymes in the human liver can impede the process of drug metabolism, that is, an essential step for administered drugs. As MBI involves bond‐forming or bond‐breaking chemical reactions, its understanding requires the use of quantum mechanical methods, and the knowledge thus obtained could usefully be exploited for the accurate prediction of P450 inhibitions. The mechanism of P450 MBI by a hydrazine compound is described in the Full Paper by H. Hirao and co‐workers on page 7361 ff.