Cover Picture: Total Synthesis of (+)‐Pleuromutilin (Chem. Eur. J. 21/2013) | Zendy

Fazakerley Neal J. | Zendy; Helm Matthew D. | Zendy; Procter David J. | Zendy

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Cover Picture: Total Synthesis of (+)‐Pleuromutilin (Chem. Eur. J. 21/2013)

Author(s) -

Fazakerley Neal J.,

Helm Matthew D.,

Procter David J.

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Reports

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201390073

Subject(s) - cover (algebra) , total synthesis , natural product , cascade , tricyclic , chemistry , stereochemistry , combinatorial chemistry , core (optical fiber) , computer science , engineering , mechanical engineering , telecommunications , chromatography

The first enantiospecific total synthesis of (+)‐pleuromutilin is reported. A SmI 2 ‐mediated cyclisation cascade allows access to the tricyclic core of the antibacterial natural product, constructing the five‐ and eight‐membered rings in a single step, with high diastereocontrol. For more details, see the Full Paper by D. J. Procter et al. on page 6718 ff.

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