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Cover Picture: Total Synthesis of (+)‐Pleuromutilin (Chem. Eur. J. 21/2013)
Author(s) -
Fazakerley Neal J.,
Helm Matthew D.,
Procter David J.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201390073
Subject(s) - cover (algebra) , total synthesis , natural product , cascade , tricyclic , chemistry , stereochemistry , combinatorial chemistry , core (optical fiber) , computer science , engineering , mechanical engineering , telecommunications , chromatography
The first enantiospecific total synthesis of (+)‐pleuromutilin is reported. A SmI 2 ‐mediated cyclisation cascade allows access to the tricyclic core of the antibacterial natural product, constructing the five‐ and eight‐membered rings in a single step, with high diastereocontrol. For more details, see the Full Paper by D. J. Procter et al. on page 6718 ff.