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Cover Picture: Total Synthesis and Biological Evaluation of (+)‐Gambieric Acid A and Its Analogues (Chem. Eur. J. 17/2013)
Author(s) -
Ishigai Kazuya,
Fuwa Haruhiko,
Hashizume Keisuke,
Fukazawa Ryo,
Cho Yuko,
YotsuYamashita Mari,
Sasaki Makoto
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201390057
Subject(s) - total synthesis , ring closing metathesis , chemistry , stereochemistry , ring (chemistry) , ether , antifungal , metathesis , salt metathesis reaction , cover (algebra) , convergent synthesis , combinatorial chemistry , organic chemistry , biology , mechanical engineering , microbiology and biotechnology , polymerization , engineering , polymer
The first total synthesis of (+)‐gambieric acid A, a potent antifungal marine polycyclic ether, has been accomplished by H. Fuwa, M. Sasaki et al. in their Full Paper on page 5276 ff. in a convergent manner by relying on Suzuki–Miyaura reaction for the assembly of the A/BCD‐ and F′GHIJ‐ring fragments and a ring‐closing metathesis for formation of the nonacyclic backbone. The total synthesis unambiguously establishes the structure of this extraordinary complex molecule, thus demonstrating the important role of organic synthesis in the structural elucidation of natural products.