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Cover Picture: Cascade Syntheses Routes to the Centrocountins (Chem. Eur. J. 7/2013)
Author(s) -
EschenbrennerLux Vincent,
Dückert Heiko,
Khedkar Vivek,
Bruss Hanna,
Waldmann Herbert,
Kumar Kamal
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201390017
Subject(s) - chemistry , cascade , cascade reaction , domino , intramolecular force , stereoselectivity , molecule , combinatorial chemistry , stereochemistry , organic chemistry , catalysis , chromatography
The longest cascade reaction sequence known to date provides natural‐product‐inspired and biologically active centrocountins, or tetrahydroindoloquinolizines and related molecules. K. Kumar, H. Waldmann et al. unravel mechanistic insights into this long cascade reaction sequence in their Full Paper on page 2294 ff. by isolating and characterizing various intermediates and with control experiments. The cover picture shows a natural setup as a symbolic source of inspiration. As the reaction substrates in the pool of water flow in different streams, representing different cascade reaction sequences, they are progressively transformed into different intermediates before settling as a collection of products, the tetrahydro(indolo)quinolizine molecules.