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Palladium(II)‐Catalyzed ortho ‐CH Arylation/Alkylation of N ‐Benzoyl α‐Amino Ester Derivatives
Author(s) -
Misal Castro Luis C.,
Chatani Naoto
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304978
Subject(s) - palladium , alkylation , chemistry , catalysis , medicinal chemistry , organic chemistry
The palladium‐catalyzed arylation/alkylation of ortho ‐CH bonds in N ‐benzoyl α‐amino ester derivatives is described. In such a system both the NH‐amido and the CO 2 R groups in the α‐amino ester moieties play a role in successful CH activation/CC bond formation using iodoaryl coupling partners. A wide variety of functional groups and electron‐rich/deficient iodoarenes are tolerated. The yields obtained range from 20 to 95 %.