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Nucleic Acid Based Logical Systems
Author(s) -
Han Da,
Kang Huaizhi,
Zhang Tao,
Wu Cuichen,
Zhou Cuisong,
You Mingxu,
Chen Zhuo,
Zhang Xiaobing,
Tan Weihong
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304891
Subject(s) - nucleic acid , computer science , synthetic biology , logical conjunction , computational biology , nanotechnology , biochemical engineering , biology , engineering , biochemistry , materials science , programming language
Researchers increasingly visualize a significant role for artificial biochemical logical systems in biological engineering, much like digital logic circuits in electrical engineering. Those logical systems could be utilized as a type of servomechanism to control nanodevices in vitro, monitor chemical reactions in situ, or regulate gene expression in vivo. Nucleic acids (NA), as carriers of genetic information with well‐regulated and predictable structures, are promising materials for the design and engineering of biochemical circuits. A number of logical devices based on nucleic acids (NA) have been designed to handle various processes for technological or biotechnological purposes. This article focuses on the most recent and important developments in NA‐based logical devices and their evolution from in vitro, through cellular, even towards in vivo biological applications.