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Acetylcholine‐Triggered Cargo Release from Supramolecular Nanovalves Based on Different Macrocyclic Receptors
Author(s) -
Zhou Yue,
Tan LiLi,
Li QingLan,
Qiu XiLong,
Qi AiDi,
Tao Yanchun,
Yang YingWei
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304864
Subject(s) - acetylcholine , cholinergic , neurotransmitter , gating , acetylcholine receptor , supramolecular chemistry , chemistry , mesoporous silica , stalk , receptor , biophysics , neuroscience , nanotechnology , mesoporous material , materials science , biochemistry , biology , molecule , pharmacology , catalysis , organic chemistry , horticulture
Abstract Acetylcholine (ACh), a neurotransmitter located in cholinergic synapses, can trigger cargo release from mesoporous silica nanoparticles equipped with calixarene‐ or pillarene‐based nanovalves by removing macrocycles from the stalk components. The amount and speed of cargo release can be controlled by varying the concentration of ACh in solution or changing the type of gating macrocycle. Although this proof‐of‐concept study is far from a real‐life application, it provides a possible route to treat diseases related to the central nervous system.