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Generation of C 2 F 5 CHN 2 In Situ and Its First Reaction: [3+2] Cycloaddition with Alkenes
Author(s) -
Mykhailiuk Pavel K.
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304840
Subject(s) - reagent , in situ , cycloaddition , chemistry , sodium nitrite , nitrite , medicinal chemistry , nuclear chemistry , inorganic chemistry , organic chemistry , catalysis , nitrate
The novel chemical reagent, C 2 F 5 CHN 2 , is generated in situ from C 2 F 5 CH 2 NH 2 ⋅ HCl and sodium nitrite. It reacts with mono‐ and disubstituted electron‐deficient alkenes at room temperature to afford C 2 F 5 ‐pyrazolines in excellent yields.