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Magnesium Complexes as Highly Effective Catalysts for Conjugate Cyanation of α,β‐Unsaturated Amides and Ketones
Author(s) -
Zhang Jinlong,
Liu Xihong,
Wang Rui
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304835
Subject(s) - cyanation , conjugate , trimethylsilyl cyanide , chemistry , bifunctional , catalysis , cyanide , organic chemistry , medicinal chemistry , combinatorial chemistry , mathematics , mathematical analysis
Asymmetric cyanation of trimethylsilyl cyanide (TMSCN) with α,β‐unsaturated amides and ketones, respectively, catalyzed by bifunctional mononuclear 1,1′‐bi‐2‐naphthol (BINOL)–Mg and binuclear bis(prophenol)–Mg catalysts was realized. A series of synthetically important 1,4‐cyano products were obtained with good to high enantioselectivities (up to 97 % ee ).
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