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Pd‐Catalyzed Decarboxylative Cross‐Coupling of 2‐Carboxyazine N ‐Oxides with Various (Hetero)aryl Halides
Author(s) -
Rouchet JeanBaptiste,
Schneider Cédric,
Spitz Cédric,
Lefèvre Johan,
Dupas George,
Fruit Corinne,
Hoarau Christophe
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304773
Subject(s) - bimetallic strip , halide , aryl , catalysis , chemistry , decarboxylation , coupling reaction , palladium , combinatorial chemistry , medicinal chemistry , organic chemistry , alkyl
Decarboxylative cross‐coupling reactions of substituted 2‐carboxyazine N ‐oxides, with a variety of (hetero)aryl halides, by bimetallic Pd 0 /Cu I and Pd 0 /Ag I catalysis are reported. Two possible pathways, a conventional bimetallic‐catalyzed decarboxylative arylation, as well as a protodecarboxylative/direct CH arylation sequence have been considered. These methods provide the first general decarboxylative arylation methodology for the 2‐carboxyazine series.