Efficient Asymmetric Hydrogenation of α‐Acetamidocinnamates through a Simple, Readily Available Monodentate Chiral  H ‐Phosphinate | Zendy

Wang XiangBo | Zendy; Goto Midori | Zendy; Han LiBiao | Zendy

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Efficient Asymmetric Hydrogenation of α‐Acetamidocinnamates through a Simple, Readily Available Monodentate Chiral H ‐Phosphinate

Author(s) -

Wang XiangBo,

Goto Midori,

Han LiBiao

Publication year - 2014

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201304675

Subject(s) - phosphinate , asymmetric hydrogenation , rhodium , intramolecular force , denticity , chemistry , asymmetric induction , catalysis , enantioselective synthesis , hydrogen bond , combinatorial chemistry , simple (philosophy) , stereochemistry , organic chemistry , molecule , crystal structure , fire retardant , philosophy , epistemology

An air‐stable, simple ( R P )‐mentylbenzylphosphinate, readily available in large quantities, can efficiently induce the rhodium‐catalyzed asymmetric hydrogenation of α‐acetamidocinnamates with high enantioselectivity (up to 99.6 % ee ). Intramolecular hydrogen bonding plays an important role in this asymmetric induction.

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