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Regioselective Ruthenium‐Catalyzed Carbonylative Direct Arylation of Five‐Membered and Condensed Heterocycles
Author(s) -
Pospech Jola,
Tlili Anis,
Spannenberg Anke,
Neumann Helfried,
Beller Matthias
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304314
Subject(s) - regioselectivity , ruthenium , catalysis , aryl , chemistry , combinatorial chemistry , carbonylation , functional group , organic chemistry , alkyl , carbon monoxide , polymer
A ruthenium‐catalyzed carbonylative CH bond arylation process for the three‐component synthesis of complex aryl–(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho ‐activating effect of nitrogen‐containing directing groups, a regioselective, successive twofold C(sp 2 )C(sp 2 ) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations.