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Palladium‐Catalyzed CH Activation and Intermolecular Annulation with Allenes
Author(s) -
Xia XiaoFeng,
Wang YuQi,
Zhang LuLu,
Song XianRong,
Liu XueYuan,
Liang YongMin
Publication year - 2014
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201304300
Subject(s) - annulation , intermolecular force , catalysis , chemistry , palladium , intramolecular force , surface modification , combinatorial chemistry , stereochemistry , organic chemistry , molecule
A new and efficient Pd II ‐catalyzed intermolecular annulation of N ‐benzoylsulfonamide with allenes for the synthesis of 3,4‐dihydroisoquinolin‐1(2 H )‐ones is reported. This CH functionalization is compatible with ambient air and moisture, and it can be applied to terminal or internal allenes with dierent synthetically attractive functional groups. Control experiments and a kinetic isotope effect study are conducted and a plausible mechanism is proposed.